All clients with neurological deficits affecting movement including:
Parkinson's is a progressive neurological condition affecting movements such as walking, talking, and writing. It is named after Dr. James Parkinson (1755-1824), the London doctor who first identified Parkinson's as a specific condition.
Parkinson's occurs as result of a loss of nerve cells in the part of the brain known as the substantia nigra. These cells are responsible for producing a chemical known as dopamine, which allows messages to be sent to the parts of the brain that co-ordinate movement. With the depletion of dopamine-producing cells, these parts of the brain are unable to function normally.
What is parkinsonism?
The main symptoms of Parkinson's can also be symptoms of other disorders. Conditions that produce these symptoms are known collectively as parkinsonism. Parkinson's is the most common form of parkinsonism and is often referred to as "idiopathic Parkinson's disease" (this means of unknown cause). Other, less common, forms of parkinsonism include:
* multiple system atrophy (MSA)
* progressive supranuclear palsy (PSP)
If you have one of these rarer conditions, the Parkinson's Disease Society can provide you with support and may be able to put you in touch with specific organisations that support people with these conditions. back to the top
The causes of Parkinsons Disease
In Parkinson's there is a loss of nerve cells in the part of the brain known as the substantia nigra.
These cells are responsible for producing a chemical known as dopamine, which allows messages to be sent to the parts of the brain that co-ordinate movement.
With the depletion of dopamine-producing cells, these parts of the brain are unable to function normally.
When about 80% of the dopamine has been lost, the symptoms of Parkinson's appear and the level of dopamine will continue to fall slowly over many years.
The reason why the loss of dopamine occurs in the brains of people with Parkinson's is currently unknown. Most researchers believe it is likely that many factors play a role in causing Parkinson's. Areas of research into the cause include genetics and environmental factors. back to the top
Genetic research
Scientists have, to date, identified nine genes linked to Parkinson's, of which the parkin gene is most commonly associated with the familial form of Parkinson's. Abnormalities in this gene are particularly prevalent with young-onset Parkinson's disease.
Research will also help to understand which factors are involved in the formation, survival and death of dopamine-producing neurons. back to the top
Environment research
There is some evidence that environmental factors (toxins) may cause dopamine-producing neurons to die, leading to the development of Parkinson's. Several toxins have been shown to cause Parkinson's-like symptoms.
There may also be a link between use of herbicides and pesticides and the development of Parkinson's.
The Signs and Symptoms of Parkinsons Disease
The symptoms of Parkinson's can be classified as motor and non-motor.
Motor symptoms define Parkinson's, with three primary features:
1. Tremor - which usually begins in one hand. This is the first symptom for 70% of people with Parkinson's
2. Slowness of movement (bradykinesia) - people with Parkinson's may find that they have difficulty initiating movements or that performing movements takes longer.
3. Stiffness or rigidity of muscles - problems with activities such as standing up from a chair or rolling over in bed may be experienced.
Various non-motor symptoms may also be experienced, for example:
* sleep disturbances
* constipation
* urinary urgency
* depression
Parkinson's tends to develop gradually and it can be a number of months or even years before the symptoms become obvious enough for a person to consult a doctor.
The NICE Guideline for Parkinson's disease (which covers England, Wales and Northern Ireland) states that people with suspected Parkinson's should be referred quickly (within 6 weeks) and untreated to a specialist with expertise in the differential diagnosis of this condition. The Guideline also recommends that the diagnosis of Parkinson's should be reviewed regularly (every 6 to 12 months).
It is not easy to diagnose Parkinson's, as there are no special tests that can prove whether or not someone has the condition. Diagnosis is usually based on medical history and a clinical examination of the person. The symptoms of Parkinson's can have other causes and laboratory tests and scans may be carried out to rule these out. back to the top
Courtesy of Parkinsons Disease Society
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